ISG15 as a novel tumor biomarker for drug sensitivity
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چکیده
منابع مشابه
ISG15 as a novel tumor biomarker for drug sensitivity.
Tumor cells are known to exhibit highly varied sensitivity to camptothecins (CPT; e.g., irinotecan and topotecan). However, the factors that determine CPT sensitivity/resistance are largely unknown. Recent studies have shown that the ubiquitin-like protein, IFN-stimulated gene 15 (ISG15), which is highly elevated in many human cancers and tumor cell lines, antagonizes the ubiquitin/proteasome p...
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Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Interferon-alpha (IFN-α) has recently been recognized to harbor therapeutic potential in prevention and treatment of HCC. IFN-stimulated gene 15 (ISG15) is an ubiquitin-like molecule that is strongly upregulated by type I interferons as a primary response to diverse microbial and cellular stress stimuli. Se...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2008
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-07-2345